Two sample MR report

Telomere_length against aparc-a2009s lh thickness G+S-cingul-Mid-Ant

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1253993	0.0994066	0.2209697
Weighted median	23	-0.0150256	0.0591072	0.7993332
Inverse variance weighted	23	0.0127559	0.0397686	0.7483982
Simple mode	23	-0.0034238	0.1003318	0.9730850
Weighted mode	23	-0.0317431	0.0708603	0.6585568

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.77812	21	0.4725644
Inverse variance weighted	23.05777	22	0.3984734

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0084828	0.0056183	0.1459813

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000702	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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