Two sample MR report

Telomere_length against aparc-a2009s lh thickness G+S-cingul-Ant

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0496040	0.0994055	0.6229620
Weighted median	23	0.0267146	0.0571645	0.6402644
Inverse variance weighted	23	0.0499994	0.0388451	0.1980431
Simple mode	23	-0.0475898	0.1082264	0.6644256
Weighted mode	23	-0.0299566	0.0857935	0.7302810

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.65315	21	0.6073794
Inverse variance weighted	19.83808	22	0.5931676

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0061157	0.0056182	0.2886899

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006513	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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