Two sample MR report

Telomere_length against aparc-a2009s lh thickness G-Ins-lg+S-cent-ins

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2033840	0.1505860	0.1911938
Weighted median	23	0.0009531	0.0600610	0.9873391
Inverse variance weighted	23	-0.0580214	0.0589784	0.3252267
Simple mode	23	0.0024944	0.1149390	0.9828814
Weighted mode	23	-0.0183440	0.0645339	0.7788743

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	48.19031	21	0.0006478
Inverse variance weighted	50.71403	22	0.0004692

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0089252	0.0085108	0.3062371

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0016041	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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