Two sample MR report

Telomere_length against aparc-a2009s lh area S-temporal-transverse

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2124078	0.1171062	0.0840242
Weighted median	23	-0.1010636	0.0544165	0.0632793
Inverse variance weighted	23	-0.0655597	0.0466444	0.1598662
Simple mode	23	-0.1377396	0.0944834	0.1590192
Weighted mode	23	-0.1117587	0.0667444	0.1082053

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.14023	21	0.1106754
Inverse variance weighted	31.71547	22	0.0823780

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0090165	0.0066186	0.1875378

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010473	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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