Two sample MR report

Telomere_length against aparc-a2009s lh area S-temporal-sup

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0628260	0.1134455	0.5855659
Weighted median	23	0.0098980	0.0561569	0.8600931
Inverse variance weighted	23	-0.0014646	0.0437014	0.9732640
Simple mode	23	0.0634056	0.0919451	0.4976541
Weighted mode	23	0.0002153	0.0684836	0.9975204

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.35055	21	0.1595490
Inverse variance weighted	27.84422	22	0.1809016

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0039474	0.0064117	0.544733

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008437	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8