Two sample MR report

Telomere_length against aparc-a2009s lh area S-temporal-inf

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0856561	0.0994060	0.3985970
Weighted median	23	0.0334023	0.0567394	0.5560640
Inverse variance weighted	23	0.0477696	0.0388454	0.2187962
Simple mode	23	0.1320157	0.1078547	0.2338941
Weighted mode	23	0.0266220	0.0725312	0.7170945

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.06055	21	0.7662397
Inverse variance weighted	18.18682	22	0.6948561

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0081923	0.0056182	0.1595869

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000597	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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