Two sample MR report

Telomere_length against aparc-a2009s lh area S-subparietal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1096770	0.1159685	0.3550327
Weighted median	23	-0.0080991	0.0551483	0.8832417
Inverse variance weighted	23	0.0032828	0.0454407	0.9424083
Simple mode	23	0.0276357	0.0808367	0.7356922
Weighted mode	23	0.0035780	0.0611986	0.9539053

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.58064	21	0.1244388
Inverse variance weighted	30.10465	22	0.1159430

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0069356	0.0065542	0.3019868

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009125	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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