Two sample MR report

Telomere_length against aparc-a2009s lh area S-suborbital

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0380223	0.1163083	0.7469722
Weighted median	23	-0.0161107	0.0588824	0.7843864
Inverse variance weighted	23	0.0094332	0.0446128	0.8325390
Simple mode	23	-0.0385750	0.0941065	0.6858374
Weighted mode	23	-0.0155786	0.0739688	0.8351304

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.74900	21	0.1201591
Inverse variance weighted	29.01798	22	0.1443481

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0029137	0.0065734	0.6621101

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008811	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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