Two sample MR report

Telomere_length against aparc-a2009s lh area S-precentral-sup-part

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0724449	0.0994065	0.4741893
Weighted median	23	-0.0465127	0.0540269	0.3892839
Inverse variance weighted	23	-0.0198531	0.0388456	0.6092959
Simple mode	23	0.0591892	0.0992838	0.5571522
Weighted mode	23	-0.0529854	0.0595779	0.3834392

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.97005	21	0.6508987
Inverse variance weighted	18.30040	22	0.6880365

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0032291	0.0056182	0.571561

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005625	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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