Two sample MR report

Telomere_length against aparc-a2009s lh area S-precentral-inf-part

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0241935	0.0994062	0.8100723
Weighted median	23	-0.0262417	0.0585690	0.6541187
Inverse variance weighted	23	-0.0236604	0.0388455	0.5424642
Simple mode	23	-0.0869093	0.0975405	0.3825669
Weighted mode	23	-0.0376712	0.0717355	0.6047384

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.69423	21	0.4777481
Inverse variance weighted	20.96774	22	0.5227324

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0029382	0.0056182	0.606461

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006466	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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