Two sample MR report

Telomere_length against aparc-a2009s lh area S-postcentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0992664	0.0994054	0.3293564
Weighted median	23	0.0559516	0.0565769	0.3226884
Inverse variance weighted	23	0.0311925	0.0388454	0.4219802
Simple mode	23	0.0415078	0.0917083	0.6552638
Weighted mode	23	0.0612886	0.0678442	0.3761140

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.25066	21	0.8585936
Inverse variance weighted	14.80414	22	0.8705052

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0041797	0.0056182	0.4651401

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004681	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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