Two sample MR report

Telomere_length against aparc-a2009s lh area S-pericallosal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0312669	0.1180797	0.7937494
Weighted median	23	0.0314568	0.0602230	0.6014343
Inverse variance weighted	23	0.0098460	0.0451230	0.8272700
Simple mode	23	0.1778607	0.1185240	0.1476674
Weighted mode	23	0.0877747	0.0744630	0.2510823

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.63095	21	0.0996587
Inverse variance weighted	29.68576	22	0.1263043

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0013152	0.0066736	0.8456597

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009015	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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