Two sample MR report

Telomere_length against aparc-a2009s lh area S-parieto-occipital

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0398448	0.1019098	0.6997493
Weighted median	23	-0.0019602	0.0594028	0.9736757
Inverse variance weighted	23	-0.0365543	0.0389092	0.3474867
Simple mode	23	-0.1533516	0.1147093	0.1949257
Weighted mode	23	0.0347535	0.0789821	0.6642174

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.07129	21	0.3954118
Inverse variance weighted	22.07258	22	0.4555636

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.000202	0.0057597	0.9723487

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006957	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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