Two sample MR report

Telomere_length against aparc-a2009s lh area S-orbital-med-olfact

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0724950	0.1302766	0.5837716
Weighted median	23	-0.0760540	0.0611567	0.2136497
Inverse variance weighted	23	-0.0733371	0.0514602	0.1541213
Simple mode	23	-0.1780951	0.1118634	0.1256351
Weighted mode	23	-0.0944626	0.0709489	0.1966839

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	36.06812	21	0.0214831
Inverse variance weighted	38.60817	22	0.0156421

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0089541	0.007363	0.2374399

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012779	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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