Two sample MR report

Telomere_length against aparc-a2009s lh area S-orbital-lateral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0629435	0.1150039	0.5899314
Weighted median	23	-0.0108202	0.0583811	0.8529645
Inverse variance weighted	23	0.0135903	0.0441342	0.7581353
Simple mode	23	-0.0417847	0.1005416	0.6817316
Weighted mode	23	-0.0233637	0.0606366	0.7037106

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.10676	21	0.1371493
Inverse variance weighted	28.39768	22	0.1628734

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0030303	0.0064998	0.6458615

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008642	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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