Two sample MR report

Telomere_length against aparc-a2009s lh area S-orbital-H-Shaped

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0188570	0.1151539	0.8714900
Weighted median	23	0.0022616	0.0588714	0.9693565
Inverse variance weighted	23	-0.0197351	0.0439646	0.6535140
Simple mode	23	-0.0452587	0.1013519	0.6595643
Weighted mode	23	0.0004131	0.0753524	0.9956752

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.17995	21	0.1351212
Inverse variance weighted	28.18004	22	0.1697910

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-5.39e-05	0.0065083	0.9934686

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008617	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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