Two sample MR report

Telomere_length against aparc-a2009s lh area S-oc-temp-med+Lingual

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0087474	0.0994066	0.9307132
Weighted median	23	0.0260607	0.0534506	0.6258569
Inverse variance weighted	23	0.0080325	0.0388455	0.8361816
Simple mode	23	0.0723706	0.0867099	0.4128980
Weighted mode	23	0.0206658	0.0657684	0.7563133

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.74447	21	0.6651125
Inverse variance weighted	17.74453	22	0.7210230

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-4.39e-05	0.0056182	0.9938396

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000539	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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