Two sample MR report

Telomere_length against aparc-a2009s lh area S-oc-temp-lat

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1735159	0.1114645	0.1344867
Weighted median	23	0.0522891	0.0546306	0.3384971
Inverse variance weighted	23	0.0121333	0.0449930	0.7874135
Simple mode	23	0.0931096	0.0890326	0.3070116
Weighted mode	23	0.0749454	0.0639480	0.2537434

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.40393	21	0.1914639
Inverse variance weighted	29.51461	22	0.1307468

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0099088	0.0062997	0.1306866

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008973	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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