Two sample MR report

Telomere_length against aparc-a2009s lh area S-oc-sup+transversal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1500285	0.1077832	0.1785065
Weighted median	23	0.0329879	0.0606485	0.5864972
Inverse variance weighted	23	0.0422687	0.0446803	0.3441365
Simple mode	23	-0.0207152	0.1252921	0.8701901
Weighted mode	23	0.0748090	0.1024829	0.4731126

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.68975	21	0.2608512
Inverse variance weighted	29.10655	22	0.1418439

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0118071	0.0060917	0.0661558

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009179	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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