Two sample MR report

Telomere_length against aparc-a2009s lh area S-oc-middle+Lunatus

Date: 22 April, 2022

Results from two sample MR:

method nsnp b se pval
MR Egger 23 0.0637513 0.1052895 0.5513446
Weighted median 23 0.0435548 0.0568974 0.4439756
Inverse variance weighted 23 0.0478006 0.0402245 0.2346968
Simple mode 23 0.1632758 0.0884346 0.0783489
Weighted mode 23 0.0549532 0.0662626 0.4158294

Heterogeneity tests

method Q Q_df Q_pval
MR Egger 23.55942 21 0.3148918
Inverse variance weighted 23.58980 22 0.3690923

Test for directional horizontal pleiotropy

egger_intercept se pval
-0.0009794 0.0059507 0.8708486

Test that the exposure is upstream of the outcome

snp_r2.exposure snp_r2.outcome correct_causal_direction steiger_pval
0.0357937 0.0007607 TRUE 0

Note - R2 values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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