Two sample MR report

Telomere_length against aparc-a2009s lh area S-occipital-ant

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0447741	0.0994055	0.6570244
Weighted median	23	0.0682169	0.0596608	0.2528675
Inverse variance weighted	23	0.0936022	0.0388452	0.0159690
Simple mode	23	0.1190786	0.1036628	0.2630120
Weighted mode	23	0.0396130	0.0846611	0.6444577

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.77304	21	0.6633181
Inverse variance weighted	20.06005	22	0.5792835

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0084963	0.0056182	0.1453653

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007838	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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