Two sample MR report

Telomere_length against aparc-a2009s lh area S-intrapariet+P-trans

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0319695	0.0994056	0.7509300
Weighted median	23	-0.0200454	0.0588781	0.7335133
Inverse variance weighted	23	0.0013688	0.0388452	0.9718910
Simple mode	23	-0.0317184	0.1062961	0.7682009
Weighted mode	23	-0.0687931	0.0778768	0.3865948

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.54214	21	0.4871919
Inverse variance weighted	20.67489	22	0.5409007

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.002047	0.0056182	0.7192422

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006265	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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