Two sample MR report

Telomere_length against aparc-a2009s lh area S-interm-prim-Jensen

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0794769	0.0994482	0.4331333
Weighted median	23	0.0359444	0.0537397	0.5035839
Inverse variance weighted	23	0.0297096	0.0388635	0.4445927
Simple mode	23	0.0379909	0.0810756	0.6439753
Weighted mode	23	0.0400819	0.0590825	0.5045887

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	9.238967	21	0.9872058
Inverse variance weighted	9.534541	22	0.9900566

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0030558	0.0056207	0.5923959

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0003066	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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