Two sample MR report

Telomere_length against aparc-a2009s lh area S-front-sup

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0151887	0.0994054	0.8800183
Weighted median	23	-0.1175980	0.0567313	0.0381822
Inverse variance weighted	23	-0.0992102	0.0388451	0.0106494
Simple mode	23	-0.2280886	0.0917096	0.0209496
Weighted mode	23	-0.1149304	0.0637331	0.0850545

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.90500	21	0.5272855
Inverse variance weighted	20.74819	22	0.5363434

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0051589	0.0056182	0.3689123

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008264	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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