Two sample MR report

Telomere_length against aparc-a2009s lh area S-front-middle

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1508882	0.1001858	0.1469406
Weighted median	23	0.0110926	0.0569641	0.8456046
Inverse variance weighted	23	-0.0497155	0.0423407	0.2403232
Simple mode	23	0.0154762	0.0912241	0.8668357
Weighted mode	23	0.0188728	0.0638719	0.7703990

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.33079	21	0.4389081
Inverse variance weighted	26.13718	22	0.2458386

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0123169	0.0056622	0.0411773

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008416	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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