Two sample MR report

Telomere_length against aparc-a2009s lh area S-front-inf

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1724712	0.1150233	0.1486422
Weighted median	23	-0.0965513	0.0571922	0.0913746
Inverse variance weighted	23	-0.0470022	0.0453593	0.3000991
Simple mode	23	-0.1627816	0.1051786	0.1359679
Weighted mode	23	-0.1319852	0.0705746	0.0748283

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.11737	21	0.1368538
Inverse variance weighted	29.99765	22	0.1185216

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0077038	0.0065009	0.2492395

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009533	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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