Two sample MR report

Telomere_length against aparc-a2009s lh area S-collat-transv-post

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0479914	0.0994063	0.6342465
Weighted median	23	0.0443118	0.0563521	0.4316694
Inverse variance weighted	23	0.0361475	0.0388455	0.3520889
Simple mode	23	0.1685428	0.1111373	0.1436242
Weighted mode	23	0.0701368	0.0706130	0.3313851

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.52568	21	0.7394265
Inverse variance weighted	17.37121	22	0.7425504

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0051661	0.0056182	0.3682612

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005527	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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