Two sample MR report

Telomere_length against aparc-a2009s lh area S-collat-transv-ant

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1764699	0.1132446	0.1341041
Weighted median	23	-0.1681664	0.0559681	0.0026586
Inverse variance weighted	23	-0.1820084	0.0432391	0.0000256
Simple mode	23	-0.1622046	0.0838276	0.0659528
Weighted mode	23	-0.1898365	0.0632677	0.0065865

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.25644	21	0.1625252
Inverse variance weighted	27.26011	22	0.2015134

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0003401	0.0064004	0.9581289

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0014913	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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