Two sample MR report

Telomere_length against aparc-a2009s lh area S-circular-insula-sup

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2778775	0.0994036	0.0108397
Weighted median	23	-0.0829104	0.0582621	0.1547191
Inverse variance weighted	23	-0.0818689	0.0393323	0.0373914
Simple mode	23	0.0135522	0.1103588	0.9033798
Weighted mode	23	-0.0730155	0.0801041	0.3719085

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.96701	21	0.6510911
Inverse variance weighted	22.55594	22	0.4271549

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0120351	0.0056181	0.0440564

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000818	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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