Two sample MR report

Telomere_length against aparc-a2009s lh area S-circular-insula-inf

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0220521	0.1348803	0.8716926
Weighted median	23	-0.0168655	0.0562299	0.7642237
Inverse variance weighted	23	-0.0167318	0.0514979	0.7452543
Simple mode	23	0.0390887	0.1020489	0.7053670
Weighted mode	23	-0.0535367	0.0709108	0.4582640

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	38.66304	21	0.0107651
Inverse variance weighted	38.66642	22	0.0154053

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0003267	0.0076231	0.9662244

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011772	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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