Two sample MR report

Telomere_length against aparc-a2009s lh area S-circular-insula-ant

Date: 22 April, 2022

Results from two sample MR:

method nsnp b se pval
MR Egger 23 0.1593283 0.1061597 0.1482847
Weighted median 23 0.0122419 0.0543389 0.8217556
Inverse variance weighted 23 0.0176397 0.0425119 0.6781889
Simple mode 23 0.0003051 0.0863106 0.9972116
Weighted mode 23 0.0065695 0.0638565 0.9189913

Heterogeneity tests

method Q Q_df Q_pval
MR Egger 23.95025 21 0.2954752
Inverse variance weighted 26.34803 22 0.2370398

Test for directional horizontal pleiotropy

egger_intercept se pval
-0.0086997 0.0059999 0.1618389

Test that the exposure is upstream of the outcome

snp_r2.exposure snp_r2.outcome correct_causal_direction steiger_pval
0.0357937 0.0008046 TRUE 0

Note - R2 values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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