Two sample MR report

Telomere_length against aparc-a2009s lh area S-cingul-Marginalis

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0067174	0.1196525	0.9557606
Weighted median	23	-0.1256532	0.0596193	0.0350661
Inverse variance weighted	23	-0.0433458	0.0459064	0.3450565
Simple mode	23	-0.1364722	0.1122171	0.2368181
Weighted mode	23	-0.1239251	0.0833291	0.1511609

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.42633	21	0.0837499
Inverse variance weighted	30.72568	22	0.1018669

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0030739	0.0067625	0.6540987

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009687	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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