Two sample MR report

Telomere_length against aparc-a2009s lh area S-central

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0935971	0.1190239	0.4404337
Weighted median	23	0.0088268	0.0573790	0.8777413
Inverse variance weighted	23	0.0205035	0.0466005	0.6599489
Simple mode	23	0.0515105	0.1023453	0.6197545
Weighted mode	23	-0.0010817	0.0713846	0.9880466

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.10672	21	0.0898643
Inverse variance weighted	31.66167	22	0.0833499

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0070057	0.0067269	0.309512

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009678	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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