Two sample MR report

Telomere_length against aparc-a2009s lh area S-calcarine

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0402939	0.1167766	0.7334879
Weighted median	23	0.0200644	0.0605807	0.7404930
Inverse variance weighted	23	0.0261960	0.0446029	0.5569915
Simple mode	23	-0.0262592	0.1246679	0.8351124
Weighted mode	23	0.0682294	0.1171472	0.5662030

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.98243	21	0.1144241
Inverse variance weighted	29.00617	22	0.1446848

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0008656	0.0066	0.8969014

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008927	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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