Two sample MR report

Telomere_length against aparc-a2009s lh area Pole-temporal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0685753	0.1498319	0.6518812
Weighted median	23	-0.1424535	0.0617114	0.0209778
Inverse variance weighted	23	-0.1008950	0.0572801	0.0781654
Simple mode	23	-0.2607772	0.1082257	0.0247805
Weighted mode	23	-0.1955264	0.0731397	0.0138839

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	47.71347	21	0.0007522
Inverse variance weighted	47.83824	22	0.0011396

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0019845	0.0084683	0.8169905

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0016539	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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