Two sample MR report

Telomere_length against aparc-a2009s lh area Lat-Fis-post

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0587397	0.0996997	0.5620349
Weighted median	23	-0.0712090	0.0614431	0.2464803
Inverse variance weighted	23	-0.0754642	0.0388451	0.0520529
Simple mode	23	-0.2112665	0.1161883	0.0826592
Weighted mode	23	-0.0186033	0.0956736	0.8476117

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.12443	21	0.4513678
Inverse variance weighted	21.15784	22	0.5110023

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0010269	0.0056348	0.8571428

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007555	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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