Two sample MR report

Telomere_length against aparc-a2009s lh area Lat-Fis-ant-Vertical

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0929687	0.0994073	0.3603006
Weighted median	23	-0.0189798	0.0565488	0.7371452
Inverse variance weighted	23	0.0019723	0.0388459	0.9595068
Simple mode	23	0.0506261	0.1125010	0.6571093
Weighted mode	23	-0.1247804	0.0758228	0.1140419

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.12820	21	0.7033060
Inverse variance weighted	18.20476	22	0.6937815

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0058294	0.0056183	0.3112696

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005517	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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