Two sample MR report

Telomere_length against aparc-a2009s lh area G-temp-sup-Plan-tempo

Date: 22 April, 2022

Results from two sample MR:

method nsnp b se pval
MR Egger 23 0.0308097 0.0994054 0.7596614
Weighted median 23 -0.0578972 0.0569408 0.3092504
Inverse variance weighted 23 -0.0513375 0.0388451 0.1863036
Simple mode 23 -0.0325026 0.1089983 0.7683533
Weighted mode 23 -0.1547787 0.1052063 0.1553993

Heterogeneity tests

method Q Q_df Q_pval
MR Egger 15.50125 21 0.7969870
Inverse variance weighted 16.30724 22 0.8003502

Test for directional horizontal pleiotropy

egger_intercept se pval
-0.0050439 0.0056182 0.3794859

Test that the exposure is upstream of the outcome

snp_r2.exposure snp_r2.outcome correct_causal_direction steiger_pval
0.0357937 0.0005471 TRUE 0

Note - R2 values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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