Two sample MR report

Telomere_length against aparc-a2009s lh area G-temp-sup-Plan-polar

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0356506	0.1144924	0.7585823
Weighted median	23	-0.0031559	0.0544029	0.9537414
Inverse variance weighted	23	0.0086151	0.0438952	0.8444029
Simple mode	23	-0.0228425	0.0844036	0.7891949
Weighted mode	23	-0.0120698	0.0541581	0.8256987

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.85767	21	0.1442345
Inverse variance weighted	28.09169	22	0.1726622

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0027179	0.0064708	0.6787352

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008527	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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