Two sample MR report

Telomere_length against aparc-a2009s lh area G-temp-sup-Lateral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0227067	0.1062790	0.8328795
Weighted median	23	-0.0321034	0.0567949	0.5719029
Inverse variance weighted	23	-0.0538673	0.0411638	0.1906673
Simple mode	23	-0.0660700	0.0902743	0.4719669
Weighted mode	23	-0.0287769	0.0649336	0.6619665

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.00413	21	0.2928583
Inverse variance weighted	24.70446	22	0.3114157

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0047016	0.0060066	0.4425192

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008069	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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