Two sample MR report

Telomere_length against aparc-a2009s lh area G-temp-sup-G-T-transv

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0448392	0.1148419	0.7001418
Weighted median	23	-0.0657664	0.0593952	0.2681781
Inverse variance weighted	23	-0.0203537	0.0439015	0.6429180
Simple mode	23	-0.1232065	0.0987450	0.2252505
Weighted mode	23	-0.0909001	0.0716842	0.2180313

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.02827	21	0.1393514
Inverse variance weighted	28.09988	22	0.1723948

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0015034	0.0064906	0.8190695

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008598	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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