Two sample MR report

Telomere_length against aparc-a2009s lh area G-temporal-middle

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1492951	0.0994053	0.1480155
Weighted median	23	-0.0343819	0.0586031	0.5574108
Inverse variance weighted	23	0.0401796	0.0413852	0.3316138
Simple mode	23	-0.0142003	0.1382910	0.9191440
Weighted mode	23	-0.0623352	0.0733792	0.4047563

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.68338	21	0.4784199
Inverse variance weighted	24.97133	22	0.2984477

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0116338	0.0056182	0.0508994

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007891	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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