Two sample MR report

Telomere_length against aparc-a2009s lh area G-temporal-inf

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0012604	0.1039203	0.9904375
Weighted median	23	-0.0045021	0.0607543	0.9409287
Inverse variance weighted	23	-0.0327981	0.0397957	0.4098474
Simple mode	23	0.1239758	0.1185753	0.3071237
Weighted mode	23	0.0332860	0.0887337	0.7111614

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.95159	21	0.3465650
Inverse variance weighted	23.09014	22	0.3966546

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0020912	0.0058734	0.7253566

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007213	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8