Two sample MR report

Telomere_length against aparc-a2009s lh area G-subcallosal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0279175	0.0994084	0.7815838
Weighted median	23	0.0418276	0.0555297	0.4513013
Inverse variance weighted	23	0.0262332	0.0388467	0.4994853
Simple mode	23	0.0700930	0.0940750	0.4641120
Weighted mode	23	0.0578168	0.0663705	0.3930944

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.98081	21	0.5224773
Inverse variance weighted	20.33102	22	0.5623424

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0033249	0.0056184	0.5603117

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006299	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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