Two sample MR report

Telomere_length against aparc-a2009s lh area G-rectus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1280056	0.1086652	0.2519813
Weighted median	23	-0.0054654	0.0573094	0.9240234
Inverse variance weighted	23	-0.0319047	0.0439398	0.4677771
Simple mode	23	-0.0318317	0.1101161	0.7752311
Weighted mode	23	0.0167529	0.0624627	0.7910398

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.09366	21	0.2431305
Inverse variance weighted	28.14776	22	0.1708360

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0098185	0.0061415	0.1248238

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008734	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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