Two sample MR report

Telomere_length against aparc-a2009s lh area G-precuneus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0797547	0.1308803	0.5488152
Weighted median	23	-0.0231016	0.0576265	0.6885042
Inverse variance weighted	23	0.0281264	0.0509135	0.5806506
Simple mode	23	-0.1018723	0.1075661	0.3538924
Weighted mode	23	-0.0270340	0.0682263	0.6957454

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	36.40366	21	0.0196884
Inverse variance weighted	37.79371	22	0.0193224

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0066238	0.007397	0.3806835

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001161	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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