Two sample MR report

Telomere_length against aparc-a2009s lh area G-precentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0705629	0.0994062	0.4856087
Weighted median	23	-0.0548560	0.0555355	0.3232676
Inverse variance weighted	23	-0.0420993	0.0388455	0.2784705
Simple mode	23	-0.0451220	0.0813616	0.5847727
Weighted mode	23	-0.0527277	0.0639473	0.4184782

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	12.16385	21	0.9350884
Inverse variance weighted	12.26062	22	0.9517607

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0017477	0.0056182	0.7588133

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004071	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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