Two sample MR report

Telomere_length against aparc-a2009s lh area G-postcentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0845407	0.0994068	0.4046665
Weighted median	23	-0.0167687	0.0552288	0.7614156
Inverse variance weighted	23	-0.0018397	0.0388456	0.9622260
Simple mode	23	-0.0358809	0.0885733	0.6893174
Weighted mode	23	-0.0358809	0.0616657	0.5665755

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.39517	21	0.8520343
Inverse variance weighted	15.21204	22	0.8529787

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0050778	0.0056182	0.3763478

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004611	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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