Two sample MR report

Telomere_length against aparc-a2009s lh area G-pariet-inf-Supramar

Date: 22 April, 2022

Results from two sample MR:

method nsnp b se pval
MR Egger 23 -0.0406920 0.1011192 0.6914449
Weighted median 23 -0.1091630 0.0562258 0.0521961
Inverse variance weighted 23 -0.1137877 0.0391691 0.0036721
Simple mode 23 -0.1108469 0.0995259 0.2774076
Weighted mode 23 -0.1108469 0.0614990 0.0851981

Heterogeneity tests

method Q Q_df Q_pval
MR Egger 21.73055 21 0.4151769
Inverse variance weighted 22.36872 22 0.4380737

Test for directional horizontal pleiotropy

egger_intercept se pval
-0.0044881 0.005715 0.4410426

Test that the exposure is upstream of the outcome

snp_r2.exposure snp_r2.outcome correct_causal_direction steiger_pval
0.0357937 0.0009378 TRUE 0

Note - R2 values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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