Two sample MR report

Telomere_length against aparc-a2009s lh area G-pariet-inf-Angular

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1069464	0.1220072	0.3906439
Weighted median	23	-0.0261004	0.0565953	0.6446725
Inverse variance weighted	23	0.0178349	0.0479303	0.7098170
Simple mode	23	-0.0792588	0.1024955	0.4475802
Weighted mode	23	-0.0328820	0.0668246	0.6275488

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.63418	21	0.0637320
Inverse variance weighted	33.49382	22	0.0552571

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0076615	0.0068955	0.2790928

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010213	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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